Tuesday June 3rd 2008

Ok here are some things from UW I did yesterday:

1. In lac operon (genetic regulation)
1. lactose induces gene expression by preventing binding of repressor protein which binds to the operator region.
2. glucose represses gene expression by reducing cAMP; causing poor binding of catabolite activator protein (CAP).
2. MHC class II needs lysosomal acidification to express itself.
3. Oral bioavailability = oral route/IV route (at the same dose)
4. Imperforate anus is associated with:
1. urogenital tract anomalies (urorectal, urovesical, urovaginal fistulas) – meconium may discharge from urethra/vagina
2. renal agenesis, hypospadias, epispadias, bladder extrophy
3. VACTERL = vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal defects, limb defects.
5. Enteric bacteria that may cause sepsis: E.Coli, Salmonella typhi, pseudomonas, klebsiella and proteus.
6. Bacteria that cause proliferation of mesenteric lymph nodes are salmonella typhi and yersinia enterocolitica.
7. Shigellosis is bacterial infection that causes mucosal invasion, along with EIEC. Clinical manifestations include cramping abdominal pain, pus and bloody diarrhea in late manifestations. It enters M-cells in Peyer’s patches, disabling 60s ribosomal subunit -> failing protein synthesis in host and mucosal cell death.

I did UW again today 40 questions. And I am proud that my score has improved a significant 15-20% and I am quite happy. But that improvement has not reached the real target that I want, so I shouldn’t get really complacent. But for the time being, a little happy and grateful is fine.

Yep, that’s my motivation besides the very superb Goljan lectures!